Autophagy-mediated turnover of Dynamin-related Protein 1
نویسندگان
چکیده
منابع مشابه
SENP3-mediated DeSUMOylation of dynamin-related protein 1 Promotes Cell Death Following Ischemia
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متن کاملSENP3-mediated deSUMOylation of dynamin-related protein 1 promotes cell death following ischaemia
Global increases in small ubiquitin-like modifier (SUMO)-2/3 conjugation are a neuroprotective response to severe stress but the mechanisms and specific target proteins that determine cell survival have not been identified. Here, we demonstrate that the SUMO-2/3-specific protease SENP3 is degraded during oxygen/glucose deprivation (OGD), an in vitro model of ischaemia, via a pathway involving t...
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Mitochondrial dynamics are known to have an important role in so-called age-related diseases, including cancer. Mitochondria is an organelle involved in many key cellular functions and responds to physiologic or stress stimuli by adapting its structure and function. Perhaps the most important structural changes involve mitochondrial dynamics (fission and fusion), which occur in normal cells as ...
متن کاملAutophagy in protein and organelle turnover.
Macroautophagy is an evolutionarily conserved degradation system in the cell. In autophagy, intracellular components are sequestered by autophagosomes and subsequently degraded upon fusion with lysosomes. Genetic analysis of autophagy in mammals has revealed that autophagy is important for various physiological processes, such as adaptive responses to starvation, embryogenesis, quality control ...
متن کاملRole of dynamin-related protein 1 (Drp1)-mediated mitochondrial fission in oxygen sensing and constriction of the ductus arteriosus.
RATIONALE Closure of the ductus arteriosus (DA) is essential for the transition from fetal to neonatal patterns of circulation. Initial PO2-dependent vasoconstriction causes functional DA closure within minutes. Within days a fibrogenic, proliferative mechanism causes anatomic closure. Though modulated by endothelial-derived vasodilators and constrictors, O2 sensing is intrinsic to ductal smoot...
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ژورنال
عنوان ژورنال: BMC Neuroscience
سال: 2013
ISSN: 1471-2202
DOI: 10.1186/1471-2202-14-86